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Ligand · U0N

U0N · 4-amino-2-[(1,3-dimethyl-1H-pyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2, 3-d]pyrimidine-5-carbonitrile

U0N, 4-amino-2-[(1,3-dimethyl-1H-pyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2, 3-d]pyrimidine-5-carbonitrile (C18 H23 N9, 365.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
U0N
Formula
C18 H23 N9
Class
ligand
Structures
2
PDB entries
1

Binding sites

U0N in 2 structures; the first of them:

  • 7BK1 · Crystal structure of CHK1-10pt-mutant complex with compound 32 · U0N A301 · binds LEU15, GLY16, GLU17, GLY18, VAL23, ALA36, ILE68, MET84 and 10 more
  • 7BK1 · Crystal structure of CHK1-10PT-mutant complex with compound 32 · U0N A301 · binds LEU15, GLY16, GLU17, GLY18, VAL23, ALA36, ILE68, MET84 and 10 more

Residues it binds most

ALA 2, GLY 2, LEU 2, GLU 2, ASN 2, ASP 2, HIS 2, ILE 2, MET 2, SER 2 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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