GL1X · GenesisL1 explorer

Ligand · U0K

U0K · 4-amino-7-methyl-2-({5-methyl-1-[(3R)-oxolan-3-yl]-1H-pyrazol-4-yl}amino)-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

U0K, 4-amino-7-methyl-2-({5-methyl-1-[(3R)-oxolan-3-yl]-1H-pyrazol-4-yl}amino)-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (C21 H27 N9 O, 421.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
U0K
Formula
C21 H27 N9 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

U0K in 2 structures; the first of them:

  • 7BK2 · Crystal structure of CHK1-10pt-mutant complex with compound 44 · U0K A301 · binds GLN13, LEU15, GLY16, GLU17, GLY18, VAL23, ALA36, ILE68 and 11 more
  • 7BK2 · Crystal structure of CHK1-10PT-mutant complex with compound 44 · U0K A301 · binds GLN13, LEU15, GLY16, GLU17, GLY18, VAL23, ALA36, ILE68 and 11 more

Residues it binds most

ALA 2, GLY 2, LEU 2, GLU 2, ASN 2, ASP 2, GLN 2, HIS 2, ILE 2, MET 2 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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