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Ligand · TVW

TVW · 1H-pyrazolo[3,4-d]pyrimidin-4-amine

TVW, 1H-pyrazolo[3,4-d]pyrimidin-4-amine (C5 H5 N5, 135.1 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
TVW
Formula
C5 H5 N5
Class
ligand
Structures
4
PDB entries
2

Binding sites

TVW in 4 structures; the first of them:

  • 7BJJ · Crystal structure of CHK1-10pt-mutant complex with compound 9 · TVW A301 · binds LEU15, VAL23, ALA36, ILE68, MET84, GLU85, LEU86, ALA87 and 1 more
  • 7BKO · Crystal structure of CHK1 complex with compound 9 · TVW A301 · binds LEU15, GLY16, VAL23, ALA36, GLU85, TYR86, CYS87, GLU91 and 2 more
  • 7BJJ · Crystal structure of CHK1-10PT-mutant complex with compound 9 · TVW A301 · binds LEU15, VAL23, ALA36, ILE68, MET84, GLU85, LEU86, ALA87 and 1 more
  • 7BKO · Crystal structure of CHK1 complex with compound 9 · TVW A301 · binds LEU15, VAL23, ALA36, GLU85, TYR86, CYS87, LEU137

Residues it binds most

LEU 4, ALA 4, GLU 4, VAL 4, CYS 2, ILE 2, MET 2, TYR 2, GLY 1, SER 1 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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