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Ligand · TVK

TVK · (3~{R})-2-[(5-chloranylpyridin-2-yl)methyl]-3-(4-chlorophenyl)-4-fluoranyl-3-[[1-(hydroxymethyl) cyclopropyl]methoxy]-6-(2-oxidanylpropan-2-yl) isoindol-1-one

TVK, (3~{R})-2-[(5-chloranylpyridin-2-yl)methyl]-3-(4-chlorophenyl)-4-fluoranyl-3-[[1-(hydroxymethyl) cyclopropyl]methoxy]-6-(2-oxidanylpropan-2-yl) isoindol-1-one (C28 H27 Cl2 F N2 O4, 545.4 g/mol), in the MolNFT structures on GenesisL1…

Component
TVK
Formula
C28 H27 Cl2 F N2 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

TVK in 2 structures; the first of them:

  • 7BJ6 · Inhibitor of MDM2-p53 Interaction · TVK A207 · binds LEU54, PHE55, LEU57, GLY58, GLN59, ILE61, MET62, TYR67 and 10 more
  • 7BJ6 · Inhibitor of MDM2-P53 interaction · TVK A207 · binds LEU54, PHE55, LEU57, GLY58, GLN59, ILE61, MET62, GLN72 and 7 more

Residues it binds most

ILE 2, PHE 2, GLN 2, HIS 2, LEU 2, TYR 2, VAL 2, GLY 2, MET 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • DMS · Dimethyl sulfoxide
  • EDO · 1,2-ethanediol

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