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Ligand · TUZ

TUZ · 1-[[(1~{R})-2-[(5-chloranylpyridin-2-yl)methyl]-1-(4-chlorophenyl)-7-fluoranyl-3-oxidanylidene-5-(2-oxidanylpropan-2-yl)isoindol-1-yl]oxymethyl]cyclopropane-1-carboxamide

TUZ, 1-[[(1~{R})-2-[(5-chloranylpyridin-2-yl)methyl]-1-(4-chlorophenyl)-7-fluoranyl-3-oxidanylidene-5-(2-oxidanylpropan-2-yl)isoindol-1-yl]oxymethyl]cyclopropane-1-carboxamide (C28 H26 Cl2 F N3 O4, 558.4 g/mol), in the MolNFT structures on…

Component
TUZ
Formula
C28 H26 Cl2 F N3 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

TUZ in 2 structures; the first of them:

  • 7BIR · Inhibitor of MDM2-p53 Interaction · TUZ A203 · binds LEU54, PHE55, LEU57, GLY58, GLN59, ILE61, MET62, TYR67 and 10 more
  • 7BIR · Inhibitor of MDM2-P53 interaction · TUZ A203 · binds LEU54, PHE55, LEU57, GLY58, GLN59, ILE61, MET62, TYR67 and 10 more

Residues it binds most

ILE 2, PHE 2, GLN 2, HIS 2, LEU 2, TYR 2, VAL 2, GLY 2, MET 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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