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Ligand · TUW

TUW · 6-[[(1~{R})-1-(4-chlorophenyl)-7-fluoranyl-1-[[1-(hydroxymethyl)cyclopropyl]methoxy]-3-oxidanylidene-5-(2-oxidanylpropan-2-yl)isoindol-2-yl]methyl]pyridine-3-carbonitrile

TUW, 6-[[(1~{R})-1-(4-chlorophenyl)-7-fluoranyl-1-[[1-(hydroxymethyl)cyclopropyl]methoxy]-3-oxidanylidene-5-(2-oxidanylpropan-2-yl)isoindol-2-yl]methyl]pyridine-3-carbonitrile (C29 H27 Cl F N3 O4, 536.0 g/mol), in the MolNFT structures on…

Component
TUW
Formula
C29 H27 Cl F N3 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

TUW in 2 structures; the first of them:

  • 7BIV · Inhibitor of MDM2-p53 Interaction · TUW A206 · binds LEU54, PHE55, LEU57, GLY58, GLN59, ILE61, MET62, TYR67 and 10 more
  • 7BIV · Inhibitor of MDM2-P53 interaction · TUW A206 · binds LEU54, PHE55, LEU57, GLY58, GLN59, ILE61, MET62, GLN72 and 7 more

Residues it binds most

ILE 2, PHE 2, GLN 2, HIS 2, LEU 2, TYR 2, VAL 2, GLY 2, MET 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • DMS · Dimethyl sulfoxide
  • EDO · 1,2-ethanediol

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