Ligand · TTG

TTG · 2-(1-dimethylaminomethyl-2-hydroxy-8-hydroxymethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-7-yl)-2-hydroxy-butyric acid

TTG, 2-(1-dimethylaminomethyl-2-hydroxy-8-hydroxymethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-7-yl)-2-hydroxy-butyric acid (C23 H25 N3 O6, 439.5 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries).…

Component: TTG
Formula: C23 H25 N3 O6
Class: ligand
Structures: 6
PDB entries: 3

Binding sites

TTG in 6 structures; the first of them:

1K4T · Human DNA topoisomerase I (70 kda) in complex with the poison topotecan and covalent… · TTG C991 · binds DT10, TGP11, DG12, DC112, DA113, ASN352, GLU356, ARG364 and 5 more
1RR8 · Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I · TTG A1991 · binds DT10, DG11, DG12, DC112, DA113, ASN352, GLU356, ARG364 and 5 more
1RRJ · Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I · TTG B991 · binds DT10, DG11, DG12, DC112, DA113, ASN352, GLU356, ARG364 and 5 more
1K4T · Human DNA topoisomerase I (70 kda) in complex with the poison topotecan and covalent… · TTG C991 · binds DT10, TGP11, DG12, DC112, DA113, ASN352, GLU356, ARG364 and 5 more
1RR8 · Structural mechanisms of camptothecin resistance by mutations in human topoisomerase I · TTG A1991 · binds DT10, DG11, DG12, DC112, DA113, ASN352, GLU356, ARG364 and 5 more
1RRJ · Structural mechanisms of camptothecin resistance by mutations in human topoisomerase I · TTG B991 · binds DT10, DG11, DG12, DC112, DA113, ASN352, GLU356, ARG364 and 5 more

Residues it binds most

ASN 6, DG 6, ARG 6, ASP 6, DA 6, DC 6, DT 6, GLU 6, LYS 6, PTR 6 (residue and the binding sites it lines).

Found with

TTC · (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]inolizino[1,2-B]-quinoline-3, 14(4H,12H)-dione
HG · Mercury (II) ion
PG4 · Tetraethylene glycol

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