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Ligand · TRU

TRU · 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

TRU, 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (C8 H8 Cl3 N3 O4 S2, 380.7 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its…

Component
TRU
Formula
C8 H8 Cl3 N3 O4 S2
Class
ligand
Structures
4
PDB entries
2

Binding sites

TRU in 4 structures; the first of them:

  • 1ZGF · carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor · TRU A300 · binds ASN62, HIS64, ASN67, GLN92, HIS94, HIS96, GLU106, HIS119 and 10 more
  • 3ILT · Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator… · TRU B800 · binds LYS104, PRO105, PHE106, MET107, SER108, LEU239, SER242, LEU247 and 6 more
  • 1ZGF · Carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor · TRU A300 · binds ASN62, HIS64, ASN67, GLN92, HIS94, HIS96, GLU106, HIS119 and 10 more
  • 3ILT · Crystal structure of the AMPA subunit GLUR2 bound to the allosteric modulator… · TRU B800 · binds LYS104, PRO105, PHE106, MET107, SER108, LEU239, SER242, LEU247 and 6 more

Residues it binds most

SER 8, LYS 6, LEU 6, HIS 2, VAL 4, GLY 6, ILE 6, PHE 6, ASN 2, ASP 4 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • BE7 · (4-carboxyphenyl)(chloro)mercury
  • GLU · Glutamic acid

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