GL1X · GenesisL1 explorer

Ligand · TNV

TNV · [2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl-triphosphate

TNV, [2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl-triphosphate (C9 H16 N5 O10 P3, 447.2 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues…

Component
TNV
Formula
C9 H16 N5 O10 P3
Class
ligand
Structures
6
PDB entries
3

Binding sites

TNV in 6 structures; the first of them:

  • 1T05 · HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate… · TNV A823 · binds DT705, DC706, DDG822, ILE63, LYS65, ARG72, ASP110, VAL111 and 7 more
  • 3FKB · Structure of NDPK H122G and tenofovir-diphosphate · TNV D160 · binds LYS16, TYR56, GLU58, HIS59, PHE64, LEU68, ARG92, THR98 and 7 more
  • 3JSM · K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with… · TNV A823 · binds DT705, DC706, DDG822, ARG65, LYS70, ARG72, LEU74, ASP110 and 9 more
  • 1T05 · HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate… · TNV A823 · binds DT705, DC706, DDG822, ILE63, LYS65, ARG72, ASP110, VAL111 and 7 more
  • 3FKB · Structure of ndpk H122G and tenofovir-diphosphate · TNV D160 · binds LYS16, TYR56, GLU58, HIS59, PHE64, LEU68, ARG92, THR98 and 7 more
  • 3JSM · K65R mutant HIV-1 reverse transcriptase cross-linked to ds-DNA and complexed with… · TNV A823 · binds DT705, DC706, DDG822, ARG65, LYS70, ARG72, LEU74, ASP110 and 9 more

Residues it binds most

ASP 4, ARG 6, GLY 6, LYS 6, TYR 6, VAL 6, ALA 4, DC 4, DDG 4, DT 4 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • GOL · Glycerol
  • TNM · [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phosphonooxy-phosphinic acid
  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.