Ligand · TMF
TMF · 5,10-methylene-6-hydrofolic acid
TMF, 5,10-methylene-6-hydrofolic acid (C20 H21 N7 O6, 455.4 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…
- Component
- TMF
- Formula
- C20 H21 N7 O6
- Class
- ligand
- Structures
- 6
- PDB entries
- 3
Binding sites
TMF in 6 structures; the first of them:
- 1BJG · D221(169)N mutant does not promote opening of the cofactor imidazolidine ring · TMF A267 · binds ARG21, HIS51, ARG53, SER54, ILE79, GLU82, ASN169, LEU172 and 4 more
- 1JBW · FPGS-AMPPCP-folate complex · TMF A996 · binds HIS11, ARG15, PRO74, PHE75, ILE76, ARG82, GLU120, PHE121 and 3 more
- 1LCE · Lactobacillus casei thymidylate synthase ternary complex with dump and CH2THF · TMF A318 · binds LYS50, GLU60, ILE81, TRP82, TRP85, TYR146, LEU195, PRO196 and 12 more
- 1BJG · D221(169)N mutant does not promote opening of the cofactor imidazolidine ring · TMF A267 · binds ARG21, HIS51, ARG53, SER54, ILE79, GLU82, ASN169, LEU172 and 4 more
- 1JBW · Fpgs-amppcp-folate complex · TMF A996 · binds HIS11, ARG15, PRO74, PHE75, ILE76, ARG82, GLU120, PHE121 and 3 more
- 1LCE · Lactobacillus casei thymidylate synthase ternary complex with dump and CH2THF · TMF A318 · binds LYS50, GLU60, ILE81, TRP82, TRP85, TYR146, LEU195, PRO196 and 12 more
Residues it binds most
PHE 6, ARG 4, ILE 6, PRO 4, GLU 6, HIS 6, LEU 4, TYR 6, ASN 4, GLN 4 (residue and the binding sites it lines).
Found with
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