Ligand · TLG

TLG · (5R)-3-acetyl-4-hydroxy-5-methyl-5-[(1Z)-2-methylbuta-1,3-dien-1-yl]thiophen-2(5H)-one

TLG, (5R)-3-acetyl-4-hydroxy-5-methyl-5-[(1Z)-2-methylbuta-1,3-dien-1-yl]thiophen-2(5H)-one (C12 H14 O3 S, 238.3 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within…

Component: TLG
Formula: C12 H14 O3 S
Class: ligand
Structures: 6
PDB entries: 3

Binding sites

TLG in 6 structures; the first of them:

4C6U · Crystal structure of M. tuberculosis KasA in complex with TLM5 · TLG A1421 · binds CYS171, ALA215, PHE237, ASP273, VAL278, ALA279, PRO280, HIS311 and 11 more
4C6V · Crystal structure of M. tuberculosis KasA in complex with TLM5 (Soak for 5 min) · TLG A1419 · binds CYS171, ALA215, PHE237, ASP273, VAL278, ALA279, PRO280, HIS311 and 11 more
4C72 · Crystal structure of M. tuberculosis C171Q KasA in complex with TLM5 · TLG A1429 · binds GLN171, ALA215, PHE237, HIS276, MET277, VAL278, ALA279, PRO280 and 10 more
4C6U · Crystal structure of M. tuberculosis kasa in complex with TLM5 · TLG A1421 · binds CYS171, ALA215, PHE237, ASP273, VAL278, ALA279, PRO280, HIS311 and 11 more
4C6V · Crystal structure of M. tuberculosis kasa in complex with TLM5 (soak for 5 min) · TLG A1419 · binds CYS171, ALA215, PHE237, ASP273, VAL278, ALA279, PRO280, HIS311 and 11 more
4C72 · Crystal structure of M. tuberculosis C171Q kasa in complex with TLM5 · TLG A1429 · binds GLN171, ALA215, PHE237, HIS276, MET277, VAL278, ALA279, PRO280 and 10 more

Residues it binds most

GLY 8, HIS 8, PHE 8, ALA 8, THR 8, PRO 8, VAL 8, ASN 4, ASP 4, CYS 4 (residue and the binding sites it lines).

Found with

K · Potassium ion
EDO · 1,2-ethanediol
M7U · (2R)-2-(hexadecanoyloxy)-3-{[(10R)-10-methyloctadecanoyl]oxy}propyl phosphate
CL · Chloride ion

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.