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Ligand · TFM

TFM · S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea

TFM, S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea (C10 H11 F3 N2 S, 248.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the residues it binds most…

Component
TFM
Formula
C10 H11 F3 N2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

TFM in 2 structures; the first of them:

  • 1K2U · Structure of rat brain nNOS heme domain complexed with… · TFM A1820 · binds GLN478, PRO565, ALA566, VAL567, MET570, PHE584, SER585, GLY586 and 5 more
  • 1K2U · Structure of rat brain nnos heme domain complexed with S… · TFM A1820 · binds GLN478, PRO565, ALA566, VAL567, MET570, PHE584, SER585, GLY586 and 5 more

Residues it binds most

MET 4, TRP 4, ALA 4, GLN 4, GLU 4, GLY 4, PHE 4, PRO 4, SER 4, TYR 4 (residue and the binding sites it lines).

Found with

  • H4B · 5,6,7,8-tetrahydrobiopterin
  • HEM · Protoporphyrin IX containing Fe
  • ZN · Zinc ion
  • ACT · Acetate ion

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