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Ligand · T8T

T8T · 2'-deoxyguanosine-5'-O-(1-thiotriphosphate)

T8T, 2'-deoxyguanosine-5'-O-(1-thiotriphosphate) (C10 H16 N5 O12 P3 S, 523.2 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most…

Component
T8T
Formula
C10 H16 N5 O12 P3 S
Class
ligand
Structures
6
PDB entries
3

Binding sites

T8T in 6 structures; the first of them:

  • 6OIW · Structure of Escherichia coli dGTPase bound to dGTP-1-thiol · T8T A603 · binds GLN53, VAL54, HIS126, ASN186, LYS211, TYR212, LYS232, ASP268 and 8 more
  • 7A5Y · Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with Rp-dGTP-alphaS… · T8T A704 · binds GLN149, LEU150, GLY153, ARG164, HIS167, ASP207, HIS210, ALA215 and 11 more
  • 7UJN · Structure of Human SAMHD1 with Non-Hydrolysable dGTP Analog · T8T A701 · binds GLN149, LEU150, ARG164, ASP207, HIS210, HIS215, HIS233, ASP311 and 8 more

Residues it binds most

LYS 84, ARG 83, VAL 60, HIS 67, ASP 76, TYR 60, ILE 48, PHE 60, GLN 60, ASN 39 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • FE · Fe (III) ion
  • MN · Manganese (II) ion

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