Ligand · T7Z
T7Z · 4-(4-methyl-2-methylimino-3H-1,3-thiazol-5-yl)-2-[(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)amino]pyrimidine-5-carbonitrile
T7Z, 4-(4-methyl-2-methylimino-3H-1,3-thiazol-5-yl)-2-[(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)amino]pyrimidine-5-carbonitrile (C21 H23 N7 O3 S2, 485.6 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries).…
- Component
- T7Z
- Formula
- C21 H23 N7 O3 S2
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
T7Z in 4 structures; the first of them:
- 4BCH · Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine… · T7Z A1328 · binds ILE25, GLY26, PHE30, VAL33, ALA46, VAL79, PHE103, ASP104 and 9 more
- 4BCM · Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine… · T7Z A1297 · binds ILE10, GLY11, GLU12, GLY13, VAL18, ALA31, LYS33, VAL64 and 11 more
- 4BCH · Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine… · T7Z A1328 · binds ILE25, GLY26, PHE30, VAL33, ALA46, VAL79, PHE103, ASP104 and 9 more
- 4BCM · Structure of CDK2 in complex with cyclin a and a 2-amino-4- heteroaryl-pyrimidine… · T7Z A1297 · binds ILE10, GLY11, GLU12, GLY13, VAL18, ALA31, LYS33, VAL64 and 11 more
Residues it binds most
PHE 6, VAL 6, ALA 6, ASP 6, GLU 6, LEU 6, LYS 4, GLY 4, HIS 6, ILE 6 (residue and the binding sites it lines).
Found with
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