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Ligand · T1Q

T1Q · N-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide

T1Q, N-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide (C20 H23 F2 N5 O4 S, 467.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
T1Q
Formula
C20 H23 F2 N5 O4 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

T1Q in 2 structures; the first of them:

  • 4E4X · Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidi… · T1Q A801 · binds VAL471, ALA481, VAL482, LYS483, LEU505, LEU514, PHE516, ILE527 and 13 more
  • 4E4X · Crystal structure of B-RAF kinase domain in complex with a… · T1Q A801 · binds VAL471, ALA481, VAL482, LYS483, LEU505, LEU514, PHE516, ILE527 and 13 more

Residues it binds most

GLY 4, LEU 4, PHE 4, SER 4, VAL 4, ILE 4, ALA 4, ASP 4, CYS 4, GLN 4 (residue and the binding sites it lines).

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