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Ligand · SX8

SX8 · 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline

SX8, 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline (C18 H13 N7 S, 359.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues…

Component
SX8
Formula
C18 H13 N7 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

SX8 in 4 structures; the first of them:

  • 3DKF · Structure of MET receptor tyrosine kinase in complex with inhibitor SGX-523 · SX8 A1 · binds ILE1084, VAL1092, ALA1108, LEU1140, LEU1157, PRO1158, TYR1159, MET1160 and 9 more
  • 3DKG · Structure of Mutant(Y1248L) MET receptor tyrosine kinase in complex with inhibitor SGX-523 · SX8 A1 · binds ILE1084, VAL1092, ALA1108, LEU1140, LEU1157, PRO1158, TYR1159, MET1160 and 8 more
  • 3DKF · Structure of met receptor tyrosine kinase in complex with inhibitor sgx-523 · SX8 A1 · binds ILE1084, VAL1092, ALA1108, LEU1140, LEU1157, PRO1158, TYR1159, MET1160 and 9 more
  • 3DKG · Structure of MUTANT(Y1248L) met receptor tyrosine kinase in complex with inhibitor sgx-523 · SX8 A1 · binds ILE1084, VAL1092, ALA1108, LEU1140, LEU1157, PRO1158, TYR1159, MET1160 and 8 more

Residues it binds most

ALA 4, ASN 4, ASP 4, LEU 4, MET 4, TYR 4, ARG 4, ILE 4, PRO 4, VAL 4 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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