SV6 · (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide

Binding sites

SV6 in 21 structures; the first of them:

• 3SV6 · Crystal structure of NS3/4A protease in complex with Telaprevir · SV6 A1 · binds GLN1041, THR1042, PHE1043, HIS1057, ASP1081, ARG1123, ILE1132, LEU1135 and 11 more
• 3SV7 · Crystal structure of NS3/4A protease variant R155K in complex with Telaprevir · SV6 A1 · binds GLN1041, THR1042, PHE1043, HIS1057, ASP1081, ARG1123, ILE1132, LEU1135 and 11 more
• 3SV8 · Crystal structure of NS3/4A protease variant D168A in complex with Telaprevir · SV6 A1 · binds GLN1041, THR1042, PHE1043, HIS1057, ARG1123, ILE1132, LEU1135, LYS1136 and 10 more
• 3SV9 · Crystal structure of NS3/4A protease variant A156T in complex with Telaprevir · SV6 A1 · binds GLN1041, THR1042, PHE1043, HIS1057, ASP1081, ARG1123, ILE1132, LEU1135 and 11 more
• 6XQS · Room-temperature X-ray Crystal structure of SARS-CoV-2 main protease in complex with… · SV6 A401 · binds THR25, THR26, LEU27, HIS41, MET49, ASN142, GLY143, SER144 and 13 more
• 6ZRT · Crystal structure of SARS CoV2 main protease in complex with inhibitor Telaprevir · SV6 A602 · binds THR25, THR26, LEU27, HIS41, MET49, PHE140, LEU141, ASN142 and 17 more
• 7C7P · Crystal structure of the SARS-CoV-2 main protease in complex with Telaprevir · SV6 A401 · binds THR25, THR26, LEU27, HIS41, MET49, LEU141, ASN142, GLY143 and 14 more
• 7K6D · SARS-CoV-2 Main Protease Co-Crystal Structure with Telaprevir Determined from Crystals… · SV6 A402 · binds THR25, THR26, LEU27, HIS41, MET49, LEU141, ASN142, GLY143 and 16 more
• 7K6E · SARS-CoV-2 Main Protease Co-Crystal Structure with Telaprevir Determined from Crystals… · SV6 A402 · binds THR25, THR26, LEU27, HIS41, MET49, LEU141, ASN142, GLY143 and 15 more
• 7LB7 · Joint X-ray/neutron structure of SARS-CoV-2 main protease (3CL Mpro) in complex with… · SV6 A401 · binds THR25, THR26, LEU27, HIS41, MET49, LEU141, ASN142, GLY143 and 14 more
• 7NBS · Crystal structure of SARS-CoV-2 main protease (Mpro) in complex with the HCV NS3/4A… · SV6 AAA402 · binds THR25, THR26, LEU27, HIS41, MET49, LEU141, ASN142, GLY143 and 14 more
• 3SV6 · Crystal structure of NS3/4A protease in complex with telaprevir · SV6 A1 · binds GLN1041, THR1042, PHE1043, HIS1057, ASP1081, ARG1123, ILE1132, LEU1135 and 11 more
• 3SV7 · Crystal structure of NS3/4A protease variant R155K in complex with telaprevir · SV6 A1 · binds GLN1041, THR1042, PHE1043, HIS1057, ASP1081, ARG1123, ILE1132, LEU1135 and 11 more
• 3SV8 · Crystal structure of NS3/4A protease variant D168A in complex with telaprevir · SV6 A1 · binds GLN1041, THR1042, PHE1043, HIS1057, ARG1123, ILE1132, LEU1135, LYS1136 and 10 more
• 3SV9 · Crystal structure of NS3/4A protease variant A156T in complex with telaprevir · SV6 A1 · binds GLN1041, THR1042, PHE1043, HIS1057, ASP1081, ARG1123, ILE1132, LEU1135 and 11 more
• 6XQS · Room-temperature X-ray crystal structure of SARS-cov-2 main protease in complex with… · SV6 A401 · binds THR25, THR26, LEU27, HIS41, MET49, ASN142, GLY143, SER144 and 13 more
• 6ZRT · Crystal structure of SARS COV2 main protease in complex with inhibitor telaprevir · SV6 A602 · binds THR25, THR26, LEU27, HIS41, MET49, PHE140, LEU141, ASN142 and 17 more
• 7C7P · Crystal structure of the SARS-cov-2 main protease in complex with telaprevir · SV6 A401 · binds THR25, THR26, LEU27, HIS41, MET49, LEU141, ASN142, GLY143 and 14 more
• 7K6D · SARS-cov-2 main protease co-crystal structure with telaprevir determined from crystals… · SV6 A402 · binds THR25, THR26, LEU27, HIS41, MET49, LEU141, ASN142, GLY143 and 16 more
• 7K6E · SARS-cov-2 main protease co-crystal structure with telaprevir determined from crystals… · SV6 A402 · binds THR25, THR26, LEU27, HIS41, MET49, LEU141, ASN142, GLY143 and 15 more
• 7LB7 · Joint X-RAY/NEUTRON structure of SARS-cov-2 main protease (3CL mpro) in complex with… · SV6 A401 · binds THR25, THR26, LEU27, HIS41, MET49, LEU141, ASN142, GLY143 and 14 more

Residues it binds most

THR 23, LEU 23, HIS 23, SER 23, GLN 23, ARG 23, MET 15, ALA 21, ASP 21, PHE 16 (residue and the binding sites it lines).

Found with

• ZN · Zinc ion
• SO4 · Sulfate ion
• DMS · Dimethyl sulfoxide
• GOL · Glycerol
• CL · Chloride ion