Ligand · SR2
SR2 · (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
SR2, (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide (C20 H20 Br N5 O, 426.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5…
- Component
- SR2
- Formula
- C20 H20 Br N5 O
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
SR2 in 4 structures; the first of them:
- 2QLQ · Crystal structure of SRC kinase domain with covalent inhibitor RL3 · SR2 A1345 · binds LEU273, VAL281, ALA293, LYS295, MET314, VAL323, ILE336, THR338 and 10 more
- 2QQ7 · Crystal structure of drug resistant SRC kinase domain with irreversible inhibitor · SR2 A1345 · binds LEU273, VAL281, ALA293, ILE294, LYS295, GLU310, ILE336, MET338 and 11 more
- 2QLQ · Crystal structure of src kinase domain with covalent inhibitor RL3 · SR2 A1345 · binds LEU273, VAL281, ALA293, LYS295, MET314, VAL323, ILE336, THR338 and 10 more
- 2QQ7 · Crystal structure of drug resistant src kinase domain with irreversible inhibitor · SR2 A1345 · binds LEU273, VAL281, ALA293, ILE294, LYS295, GLU310, ILE336, MET338 and 11 more
Residues it binds most
LEU 8, ALA 8, ASP 8, ILE 8, MET 8, CYS 10, GLU 8, VAL 8, GLY 8, LYS 8 (residue and the binding sites it lines).
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