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Ligand · SR1

SR1 · 5-S-methyl-5-thio-alpha-D-ribofuranose

SR1, 5-S-methyl-5-thio-alpha-D-ribofuranose (C6 H12 O4 S, 180.2 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
SR1
Formula
C6 H12 O4 S
Class
sugar
Structures
8
PDB entries
4

Binding sites

SR1 in 8 structures; the first of them:

  • 1Z5N · Crystal structure of MTA/AdoHcy nucleosidase Glu12Gln mutant complexed with… · SR1 A233 · binds ALA8, MET9, GLN12, ILE50, SER76, PHE151, GLU172, MET173 and 5 more
  • 2PUN · Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of… · SR1 A998 · binds TRP74, ILE176, LEU180, ASP233, HIS235, PHE253, ARG340, ARG341 and 2 more
  • 2PYW · Structure of A. thaliana 5-methylthioribose kinase in complex with ADP and MTR · SR1 A998 · binds ASN46, LEU47, ILE69, TRP76, LEU180, VAL184, ASP238, HIS240 and 5 more
  • 4RY8 · Crystal structure of 5-methylthioribose transporter solute binding protein TLET_1677 from… · SR1 A401 · binds PHE48, PHE49, HIS98, PHE121, ASP122, GLN135, PHE166, PRO168 and 6 more
  • 1Z5N · Crystal structure of MTA/ADOHCY nucleosidase GLU12GLN mutant complexed with… · SR1 A233 · binds ALA8, MET9, GLN12, ILE50, SER76, PHE151, GLU172, MET173 and 5 more
  • 2PUN · Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of… · SR1 A998 · binds TRP74, ILE176, LEU180, ASP233, HIS235, PHE253, ARG340, ARG341 and 2 more
  • 2PYW · Structure of a. thaliana 5-methylthioribose kinase in complex with ADP and mtr · SR1 A998 · binds ASN46, LEU47, ILE69, TRP76, LEU180, VAL184, ASP238, HIS240 and 5 more
  • 4RY8 · Crystal structure of 5-methylthioribose transporter solute binding protein TLET_1677 from… · SR1 A401 · binds PHE48, PHE49, HIS98, PHE121, ASP122, GLN135, PHE166, PRO168 and 6 more

Residues it binds most

PHE 20, ARG 20, ASP 16, LEU 16, VAL 16, HIS 16, MET 12, TRP 16, ALA 12, GLN 12 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ACP · Phosphomethylphosphonic acid adenylate ester
  • ADE · Adenine
  • ADP · Adenosine-5'-diphosphate
  • CPS · 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate
  • CL · Chloride ion
  • EDO · 1,2-ethanediol

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