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Ligand · SL8

SL8 · ~{N}-[3-[(3~{R},6~{R})-5-azanyl-3,6-dimethyl-6-(trifluoromethyl)-2~{H}-1,4-oxazin-3-yl]phenyl]-5-bromanyl-pyridine-2-carboxamide

SL8, ~{N}-[3-[(3~{R},6~{R})-5-azanyl-3,6-dimethyl-6-(trifluoromethyl)-2~{H}-1,4-oxazin-3-yl]phenyl]-5-bromanyl-pyridine-2-carboxamide (C19 H18 Br F3 N4 O2, 471.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
SL8
Formula
C19 H18 Br F3 N4 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

SL8 in 2 structures; the first of them:

  • 7B1P · Crystal Structure of Human BACE-1 in Complex with Compound 38a (NB-854) · SL8 A501 · binds GLY11, GLN12, GLY13, TYR14, LEU30, ASP32, GLY34, SER35 and 11 more
  • 7B1P · Crystal structure of human bace-1 in complex with compound 38A (nb- 854) · SL8 A501 · binds GLY11, GLN12, GLY13, TYR14, LEU30, ASP32, GLY34, SER35 and 11 more

Residues it binds most

GLY 2, ASP 2, ILE 2, SER 2, THR 2, TYR 2, ALA 2, GLN 2, LEU 2, PHE 2 (residue and the binding sites it lines).

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