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Ligand · S8Z

S8Z · (8R)-8-[4-(difluoromethoxy)phenyl]-3,3-difluoro-8-[3-(3-methoxyprop-1-yn-1-yl)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine

S8Z, (8R)-8-[4-(difluoromethoxy)phenyl]-3,3-difluoro-8-[3-(3-methoxyprop-1-yn-1-yl)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine (C23 H20 F4 N4 O2, 460.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
S8Z
Formula
C23 H20 F4 N4 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

S8Z in 2 structures; the first of them:

  • 4ACX · Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED… · S8Z A1504 · binds SER10, GLY11, GLN12, GLY13, LEU30, ASP32, GLY34, SER35 and 16 more
  • 4ACX · Aminoimidazoles as bace-1 inhibitors. X-ray crystal structure of beta secretase complexed… · S8Z A1504 · binds SER10, GLY11, GLN12, GLY13, LEU30, ASP32, GLY34, SER35 and 16 more

Residues it binds most

GLY 2, SER 2, ASP 2, GLN 2, ILE 2, THR 2, TRP 2, ALA 2, ARG 2, ASN 2 (residue and the binding sites it lines).

Found with

  • ACT · Acetate ion

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