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Ligand · S4E

S4E · N-(2-(2-cyclopropylethoxy)pyrimidin-5-yl)-7-methoxy-6-(piperidin-4-ylmethoxy)quinazolin-4-amine

S4E, N-(2-(2-cyclopropylethoxy)pyrimidin-5-yl)-7-methoxy-6-(piperidin-4-ylmethoxy)quinazolin-4-amine (C24 H30 N6 O3, 450.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
S4E
Formula
C24 H30 N6 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

S4E in 2 structures; the first of them:

  • 7AVY · MerTK kinase domain in complex with quinazoline-based inhbitor · S4E A901 · binds LEU593, GLY594, VAL601, ALA617, LYS619, MET621, MET641, ILE650 and 14 more
  • 7AVY · Mertk kinase domain in complex with quinazoline-based inhbitor · S4E A901 · binds LEU593, GLY594, VAL601, ALA617, LYS619, ILE650, LEU671, PRO672 and 9 more

Residues it binds most

LEU 2, MET 2, ALA 2, ASP 2, PHE 2, GLY 2, LYS 2, VAL 2, ILE 2, PRO 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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