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Ligand · RX5

RX5 · methyl (2-{(R)-(3-chlorophenyl)[(3R)-1-({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}carbamoyl)piperidin-3-yl] methoxy}ethyl)carbamate

RX5, methyl (2-{(R)-(3-chlorophenyl)[(3R)-1-({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}carbamoyl)piperidin-3-yl] methoxy}ethyl)carbamate (C26 H41 Cl N4 O5, 525.1 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
RX5
Formula
C26 H41 Cl N4 O5
Class
ligand
Structures
2
PDB entries
1

Binding sites

RX5 in 2 structures; the first of them:

  • 3Q4B · Clinically Useful Alkyl Amine Renin Inhibitors · RX5 A335 · binds THR12, GLN13, TYR14, VAL30, ASP32, GLY34, SER35, TYR75 and 18 more
  • 3Q4B · Clinically useful alkyl amine renin inhibitors · RX5 A335 · binds THR12, GLN13, TYR14, VAL30, ASP32, GLY34, SER35, TYR75 and 18 more

Residues it binds most

ALA 4, THR 4, TYR 4, SER 4, ASP 4, GLY 4, PHE 4, VAL 4, LEU 4, GLN 4 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • CL · Chloride ion

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