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Ligand · RUF

RUF · 7-(2-chlorobenzyl)-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione

RUF, 7-(2-chlorobenzyl)-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione (C18 H21 Cl N6 O2, 388.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5…

Component
RUF
Formula
C18 H21 Cl N6 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

RUF in 2 structures; the first of them:

  • 3G0C · Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 1 · RUF A800 · binds ARG125, GLU205, GLU206, PHE357, TYR547, TRP629, SER630, TYR631 and 7 more
  • 3G0C · Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 1 · RUF A800 · binds ARG125, GLU205, GLU206, PHE357, TYR547, TRP629, SER630, TYR631 and 7 more

Residues it binds most

TYR 8, GLU 8, TRP 8, VAL 8, ASN 8, HIS 8, PHE 8, SER 8, ARG 6, GLY 6 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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