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Ligand · RQ7

RQ7 · 6-{8-[(1,3-benzothiazol-2-yl)carbamoyl]-3,4-dihydroisoquinolin-2(1H)-yl}-3-{1-[(pyridin-4-yl) methyl]-1H-pyrazol-4-yl}pyridine-2-carboxylic acid

RQ7, 6-{8-[(1,3-benzothiazol-2-yl)carbamoyl]-3,4-dihydroisoquinolin-2(1H)-yl}-3-{1-[(pyridin-4-yl) methyl]-1H-pyrazol-4-yl}pyridine-2-carboxylic acid (C32 H25 N7 O3 S, 587.7 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records…

Component
RQ7
Formula
C32 H25 N7 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

RQ7 in 2 structures; the first of them:

  • 6VWC · Crystal structure of Bcl-xL in complex with tetrahydroisoquinoline-pyridine based… · RQ7 A301 · binds ALA93, PHE97, TYR101, ARG102, PHE105, SER106, ASP107, LEU108 and 13 more
  • 6VWC · Crystal structure of BCL-xl in complex with tetrahydroisoquinoline- pyridine based… · RQ7 A301 · binds ALA93, PHE97, TYR101, ARG102, PHE105, SER106, ASP107, LEU108 and 13 more

Residues it binds most

ALA 4, ARG 4, PHE 4, LEU 4, SER 4, TYR 4, ASN 4, ASP 4, GLU 4, GLY 4 (residue and the binding sites it lines).

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