GL1X · GenesisL1 explorer

Ligand · RO7

RO7 · (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid

RO7, (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid (C24 H23 N O5 S, 437.5 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with…

Component
RO7
Formula
C24 H23 N O5 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

RO7 in 4 structures; the first of them:

  • 3G8I · Aleglitazar, a new, potent, and balanced PPAR alpha/gamma agonist for the treatment of… · RO7 A1 · binds ILE241, LEU247, VAL255, ILE272, PHE273, CYS275, CYS276, GLN277 and 17 more
  • 3G9E · Aleglitaar. a new. potent, and balanced dual ppara/g agonist for the treatment of type II… · RO7 A1 · binds ARG280, ILE281, PHE282, GLY284, CYS285, GLN286, ARG288, SER289 and 16 more
  • 3G8I · Aleglitazar, a new, potent, and balanced ppar ALPHA/GAMMA agonist for the treatment of… · RO7 A1 · binds ILE241, LEU247, VAL255, ILE272, PHE273, CYS275, CYS276, GLN277 and 17 more
  • 3G9E · Aleglitaar. a new. potent, and balanced dual PPARA/G agonist for the treatment of type II… · RO7 A1 · binds ARG280, ILE281, PHE282, GLY284, CYS285, GLN286, ARG288, SER289 and 16 more

Residues it binds most

LEU 4, ILE 4, MET 4, PHE 4, TYR 4, VAL 4, CYS 4, HIS 4, ARG 2, GLN 4 (residue and the binding sites it lines).

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