Ligand · RO6

RO6 · 3-(2-chlorophenyl)-7-[(trans-4-hydroxycyclohexyl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

RO6, 3-(2-chlorophenyl)-7-[(trans-4-hydroxycyclohexyl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (C18 H20 Cl N5 O2, 373.8 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with…

Component: RO6
Formula: C18 H20 Cl N5 O2
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

RO6 in 2 structures; the first of them:

3FSK · P38 kinase crystal structure in complex with RO6257 · RO6 A450 · binds VAL30, GLY33, VAL38, ALA51, VAL52, LYS53, GLU71, LEU75 and 11 more
3FSK · P38 kinase crystal structure in complex with RO6257 · RO6 A450 · binds VAL30, GLY33, VAL38, ALA51, VAL52, LYS53, GLU71, LEU75 and 11 more

Residues it binds most

LEU 2, VAL 2, ALA 2, ASP 2, GLY 2, GLU 2, HIS 2, ILE 2, LYS 2, MET 2 (residue and the binding sites it lines).

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