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Ligand · RK2

RK2 · 4-[2-methyl-3-[(2~{R})-2-pyridin-2-yloxypropyl]imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine

RK2, 4-[2-methyl-3-[(2~{R})-2-pyridin-2-yloxypropyl]imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine (C20 H21 N7 O, 375.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
RK2
Formula
C20 H21 N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

RK2 in 2 structures; the first of them:

  • 7AKA · Structure of DYRK1A in complex with compound 54 · RK2 A501 · binds ILE165, GLY166, PHE170, VAL173, ALA186, LYS188, GLU203, VAL222 and 11 more
  • 7AKA · Structure of DYRK1A in complex with compound 54 · RK2 A501 · binds ILE165, GLY166, PHE170, VAL173, ALA186, LYS188, GLU203, VAL222 and 11 more

Residues it binds most

GLU 4, VAL 4, PHE 4, LEU 4, ASN 4, LYS 4, ALA 4, ASP 4, GLY 4, ILE 4 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion
  • PO4 · Phosphate ion
  • DMS · Dimethyl sulfoxide

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