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Ligand · RI9

RI9 · N-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide

RI9, N-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide (C16 H20 F2 N6 O4 S, 430.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
RI9
Formula
C16 H20 F2 N6 O4 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

RI9 in 2 structures; the first of them:

  • 4EHG · B-Raf Kinase Domain in Complex with an Aminopyridimine-based Inhibitor · RI9 A801 · binds VAL471, ALA481, VAL482, LYS483, LEU505, LEU514, PHE516, ILE527 and 11 more
  • 4EHG · B-RAF kinase domain in complex with an aminopyridimine-based inhibitor · RI9 A801 · binds VAL471, ALA481, VAL482, LYS483, LEU505, LEU514, PHE516, ILE527 and 11 more

Residues it binds most

GLY 4, PHE 4, LEU 4, VAL 4, SER 4, ALA 4, ASP 4, CYS 4, GLN 4, ILE 4 (residue and the binding sites it lines).

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