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Ligand · RI8

RI8 · 4-amino-N-{2,6-difluoro-3-[(propylsulfonyl)amino]phenyl}thieno[3,2-d]pyrimidine-7-carboxamide

RI8, 4-amino-N-{2,6-difluoro-3-[(propylsulfonyl)amino]phenyl}thieno[3,2-d]pyrimidine-7-carboxamide (C16 H15 F2 N5 O3 S2, 427.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
RI8
Formula
C16 H15 F2 N5 O3 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

RI8 in 2 structures; the first of them:

  • 4EHE · B-Raf Kinase Domain in Complex with an Aminothienopyrimidine-based Inhibitor · RI8 A801 · binds VAL471, ALA481, VAL482, LYS483, LEU505, LEU514, PHE516, ILE527 and 10 more
  • 4EHE · B-RAF kinase domain in complex with an aminothienopyrimidine-based inhibitor · RI8 A801 · binds VAL471, ALA481, VAL482, LYS483, LEU505, LEU514, PHE516, ILE527 and 10 more

Residues it binds most

LEU 4, PHE 4, GLY 4, VAL 4, ALA 4, ASP 4, CYS 4, GLN 4, ILE 4, LYS 4 (residue and the binding sites it lines).

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