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Ligand · R6H

R6H · ~{N}-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluoranyl-phenyl]-4-ethoxy-1-(4-fluoranyl-2-methyl-phenyl) pyrazole-3-carboxamide

R6H, ~{N}-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluoranyl-phenyl]-4-ethoxy-1-(4-fluoranyl-2-methyl-phenyl) pyrazole-3-carboxamide (C30 H26 F2 N4 O5, 560.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
R6H
Formula
C30 H26 F2 N4 O5
Class
ligand
Structures
2
PDB entries
1

Binding sites

R6H in 2 structures; the first of them:

  • 7AAX · Crystal structure of MerTK kinase domain in complex with LDC1267 · R6H A901 · binds LEU593, VAL601, ALA617, VAL618, LYS619, PHE634, GLU637, ALA638 and 16 more
  • 7AAX · Crystal structure of mertk kinase domain in complex with LDC1267 · R6H A901 · binds LEU593, VAL601, ALA617, LYS619, PHE634, MET641, ILE650, LEU652 and 11 more

Residues it binds most

LEU 2, MET 2, PHE 2, VAL 2, ALA 2, LYS 2, ASP 2, HIS 2, ILE 2, PRO 2 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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