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Ligand · R5Z

R5Z · 1-cycloheptyl-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-4, 4-dimethyl-4,5-dihydro-1H-pyrazol-5-one

R5Z, 1-cycloheptyl-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-4, 4-dimethyl-4,5-dihydro-1H-pyrazol-5-one (C27 H34 N2 O3, 434.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
R5Z
Formula
C27 H34 N2 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

R5Z in 2 structures; the first of them:

  • 7A9V · Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-635 · R5Z B508 · binds TYR159, HIS160, MET273, LEU319, ASN321, TYR329, TRP332, THR333 and 8 more
  • 7A9V · Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor npd-635 · R5Z B508 · binds TYR159, HIS160, MET273, LEU319, ASN321, TYR329, TRP332, THR333 and 8 more

Residues it binds most

MET 6, PHE 6, TYR 6, ASN 6, GLN 6, GLY 6, HIS 6, ILE 6, LEU 6, SER 6 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ZN · Zinc ion
  • EDO · 1,2-ethanediol
  • EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
  • PEG · Di(hydroxyethyl)ether

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