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Ligand · R48

R48 · 1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea

R48, 1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea (C29 H30 N8 O, 506.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
R48
Formula
C29 H30 N8 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

R48 in 2 structures; the first of them:

  • 3GCU · Human P38 MAP kinase in complex with RL48 · R48 A401 · binds VAL30, VAL38, ALA51, LYS53, ARG67, ARG70, GLU71, LEU74 and 15 more
  • 3GCU · Human P38 MAP kinase in complex with RL48 · R48 A401 · binds VAL30, VAL38, ALA51, LYS53, ARG67, ARG70, GLU71, LEU74 and 15 more

Residues it binds most

LEU 4, ILE 4, VAL 4, ARG 4, HIS 4, MET 4, ALA 4, ASP 4, GLU 4, LYS 4 (residue and the binding sites it lines).

Found with

  • BOG · octyl beta-D-glucopyranoside
  • MES · 2-(N-morpholino)-ethanesulfonic acid

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