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Ligand · QZ8

QZ8 · 3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one

QZ8, 3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one (C13 H11 N3 O, 225.2 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
QZ8
Formula
C13 H11 N3 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

QZ8 in 2 structures; the first of them:

  • 6TPD · Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype… · QZ8 A1201 · binds LEU855, GLY856, LYS857, GLY858, VAL863, ALA880, MET929, GLU930 and 4 more
  • 6TPD · Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype… · QZ8 A1201 · binds GLY856, VAL863, ALA880, MET929, GLU930, TYR931, LEU932, GLY935 and 1 more

Residues it binds most

GLY 2, LEU 2, ALA 2, GLU 2, MET 2, TYR 2, VAL 2, LYS 1 (residue and the binding sites it lines).

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