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Ligand · QP1

QP1 · N-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl) sulfanyl]-1H-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide

QP1, N-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl) sulfanyl]-1H-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide (C27 H28 F N5 O3 S, 521.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries).…

Component
QP1
Formula
C27 H28 F N5 O3 S
Class
ligand
Structures
2
PDB entries
2

Binding sites

QP1 in 2 structures; the first of them:

  • 6V66 · EGFR(T790M/V948R) in complex with LN2899 · QP1 D1203 · binds LEU718, GLY719, SER720, VAL726, ALA743, LYS745, LEU777, LEU788 and 13 more
  • 6VHP · Wild type EGFR in complex with LN2899 · QP1 A1101 · binds LEU718, PHE723, VAL726, ALA743, LYS745, MET766, LEU777, LEU788 and 10 more

Residues it binds most

LEU 5, GLY 5, MET 5, ASP 5, ALA 5, CYS 5, GLN 5, ILE 5, LYS 5, PRO 5 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion
  • EDO · 1,2-ethanediol

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