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Ligand · QHZ

QHZ · 1-[3-[2-hydroxy-2-oxoethyl-(3-methoxyphenyl)sulfonyl-amino]phenyl]-5-[(1~{S},2~{S})-2-phenylcyclopropyl]pyrazole-4-carboxylic acid

QHZ, 1-[3-[2-hydroxy-2-oxoethyl-(3-methoxyphenyl)sulfonyl-amino]phenyl]-5-[(1~{S},2~{S})-2-phenylcyclopropyl]pyrazole-4-carboxylic acid (C28 H25 N3 O7 S, 547.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
QHZ
Formula
C28 H25 N3 O7 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

QHZ in 2 structures; the first of them:

  • 6ZF8 · Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein… · QHZ A717 · binds TYR334, SER363, GLY364, ARG380, ASN414, ARG415, ILE461, GLY462 and 11 more
  • 6ZF8 · KEAP1 kelch domain bound to a small molecule inhibitor of the KEAP1- NRF2 protein-protein… · QHZ A717 · binds TYR334, SER363, GLY364, ARG380, ASN414, ARG415, ILE461, GLY462 and 11 more

Residues it binds most

GLY 2, SER 2, ARG 2, TYR 2, PHE 2, ALA 2, ASN 2, ILE 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • DMS · Dimethyl sulfoxide

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