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Ligand · QHK

QHK · 5-cyclopropyl-1-[3-[2-hydroxy-2-oxoethyl(phenylsulfonyl)amino]phenyl]pyrazole-4-carboxylic acid

QHK, 5-cyclopropyl-1-[3-[2-hydroxy-2-oxoethyl(phenylsulfonyl)amino]phenyl]pyrazole-4-carboxylic acid (C21 H19 N3 O6 S, 441.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
QHK
Formula
C21 H19 N3 O6 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

QHK in 2 structures; the first of them:

  • 6ZF1 · Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein… · QHK A711 · binds TYR334, SER363, GLY364, ARG380, ASN414, ARG415, ILE461, GLY462 and 11 more
  • 6ZF1 · KEAP1 kelch domain bound to a small molecule inhibitor of the KEAP1- NRF2 protein-protein… · QHK A711 · binds TYR334, SER363, GLY364, ARG380, ASN414, ARG415, ILE461, GLY462 and 11 more

Residues it binds most

GLY 2, SER 2, ARG 2, TYR 2, PHE 2, ALA 2, ASN 2, ILE 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • DMS · Dimethyl sulfoxide

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