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Ligand · QFK

QFK · 7-[[4-[4-[(dimethylamino)methyl]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{N},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide

QFK, 7-[[4-[4-[(dimethylamino)methyl]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{N},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide (C20 H23 N9 O, 405.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
QFK
Formula
C20 H23 N9 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

QFK in 2 structures; the first of them:

  • 6ZCP · SYK Kinase domain in complex with azabenzimidazole inhibitor 2b · QFK A701 · binds LEU377, GLY378, SER379, PHE382, VAL385, ALA400, LYS402, VAL433 and 12 more
  • 6ZCP · Syk kinase domain in complex with azabenzimidazole inhibitor 2B · QFK A701 · binds LEU377, GLY378, SER379, PHE382, VAL385, ALA400, LYS402, MET448 and 10 more

Residues it binds most

ALA 2, GLY 2, LEU 2, MET 2, SER 2, GLU 2, VAL 2, ARG 2, ASN 2, ASP 2 (residue and the binding sites it lines).

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