GL1X · GenesisL1 explorer

Ligand · PUP

PUP · (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-({[(S)-hydroxy{[(2R,3S,4S)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy}phosphoryl]oxy}methyl)tetrahydrofuran-3-yl dihydrogen phosphate

PUP, (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-({[(S)-hydroxy{[(2R,3S,4S)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy}phosphoryl]oxy}methyl)tetrahydrofuran-3-yl dihydrogen phosphate (C14 H22 N2 O15 P2…

Component
PUP
Formula
C14 H22 N2 O15 P2
Class
ligand
Structures
2
PDB entries
1

Binding sites

PUP in 2 structures; the first of them:

  • 4OAV · Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate. · PUP D1004 · binds ARG667, LYS606, THR607, MET644, PHE647, TYR648, ARG651, TYR655 and 3 more
  • 4OAV · Complete human RNase L in complex with 2-5A (5'-ppp heptamer), amppcp and RNA substrate. · PUP D1004 · binds ARG667, LYS606, THR607, MET644, PHE647, TYR648, ARG651, TYR655 and 3 more

Residues it binds most

ARG 2, ASN 2, TYR 2, LYS 2, MET 2, PHE 2, THR 2 (residue and the binding sites it lines).

Found with

  • ACP · Phosphomethylphosphonic acid adenylate ester
  • MG · Magnesium ion
  • PO4 · Phosphate ion

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