Ligand · PTK

PTK · pyrene-1,3,6,8-tetrasulfonic acid

PTK, pyrene-1,3,6,8-tetrasulfonic acid (C16 H10 O12 S4, 522.5 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component: PTK
Formula: C16 H10 O12 S4
Class: ligand
Structures: 8
PDB entries: 4

Binding sites

PTK in 8 structures; the first of them:

3IS4 · Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK)in complex with… · PTK A501 · binds PRO187, ALA191, ARG194, ASP221, LYS224
3KTX · Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK)in complex with… · PTK A501 · binds PRO187, ALA191, ARG194, ASP221, LYS224
3PP7 · Crystal structure of Leishmania mexicana pyruvate kinase in complex with the drug… · PTK A499 · binds PRO187, ARG194, LYS224
3SRK · A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase · PTK A502 · binds ARG194, ASP221, LYS224
3IS4 · Crystal structure of leishmania mexicana pyruvate kinase (LMPYK)IN complex with… · PTK A501 · binds PRO187, ALA191, ARG194, ASP221, LYS224
3KTX · Crystal structure of leishmania mexicana pyruvate kinase (LMPYK)IN complex with… · PTK A501 · binds PRO187, ALA191, ARG194, ASP221, LYS224
3PP7 · Crystal structure of leishmania mexicana pyruvate kinase in complex with the drug… · PTK A499 · binds PRO187, ARG194, LYS224
3SRK · A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase · PTK A502 · binds ARG194, ASP221, LYS224

Residues it binds most

ARG 8, LYS 8, ASP 6, PRO 6, ALA 4 (residue and the binding sites it lines).

Found with

GOL · Glycerol
K · Potassium ion
LSA · 1,2-benzisothiazol-3(2H)-one 1,1-dioxide
SVR · 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid

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