GL1X · GenesisL1 explorer

Ligand · POZ

POZ · 2,5-anhydro-1,3,4-trideoxy-2-(2,4-difluorophenyl)-6-O-{4-[4-(4-{1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenyl}-1-(1H-1,2,4-triazol-1-yl)-D-erythro-hexitol

POZ, 2,5-anhydro-1,3,4-trideoxy-2-(2,4-difluorophenyl)-6-O-{4-[4-(4-{1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenyl}-1-(1H-1,2,4-triazol-1-yl)-D-erythro-hexitol (C37 H42 F2 N8 O4…

Component
POZ
Formula
C37 H42 F2 N8 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

POZ in 2 structures; the first of them:

  • 3K1O · Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi in… · POZ A490 · binds ILE45, VAL46, PHE48, GLY49, TYR103, MET106, PHE110, TYR116 and 18 more
  • 3K1O · Crystal structure of sterol 14-alpha demethylase (CYP51) from trypanosoma cruzi in… · POZ A490 · binds ILE45, VAL46, PHE48, GLY49, TYR103, MET106, PHE110, TYR116 and 18 more

Residues it binds most

MET 2, PHE 2, ALA 2, LEU 2, TYR 2, THR 2, VAL 2, CYS 2, GLY 2, HIS 2 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe

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