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Ligand · POX

POX · 4-amino-6-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}pyrimidine-5-carbaldehyde O-(2-methoxyethyl)oxime

POX, 4-amino-6-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}pyrimidine-5-carbaldehyde O-(2-methoxyethyl)oxime (C22 H22 F N7 O2, 435.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with…

Component
POX
Formula
C22 H22 F N7 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

POX in 2 structures; the first of them:

  • 3BEL · X-ray structure of EGFR in complex with oxime inhibitor · POX A1 · binds LEU718, VAL726, ALA743, LYS745, MET766, CYS775, ARG776, LEU777 and 13 more
  • 3BEL · X-ray structure of EGFR in complex with oxime inhibitor · POX A1 · binds LEU718, VAL726, ALA743, LYS745, MET766, CYS775, ARG776, LEU777 and 13 more

Residues it binds most

LEU 2, ASP 2, CYS 2, MET 2, THR 2, ALA 2, ARG 2, GLN 2, GLY 2, LYS 2 (residue and the binding sites it lines).

Found with

  • PO4 · Phosphate ion

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