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Ligand · POF

POF · (4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate

POF, (4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate (C24 H27 N3 O5 S, 469.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
POF
Formula
C24 H27 N3 O5 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

POF in 2 structures; the first of them:

  • 3C7P · Crystal structure of human carbonic anhydrase II in complex with STX237 · POF A265 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131, GLY132 and 10 more
  • 3C7P · Crystal structure of human carbonic anhydrase II in complex with STX237 · POF A265 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131, GLY132 and 10 more

Residues it binds most

HIS 2, VAL 2, GLN 2, LEU 2, PRO 2, THR 2, GLU 2, GLY 2, PHE 2, TRP 2 (residue and the binding sites it lines).

Found with

  • MBO · Mercuribenzoic acid
  • ZN · Zinc ion
  • CL · Chloride ion
  • GOL · Glycerol

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