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Ligand · PHY

PHY · 1(S)-aminoethyl-(2-carboxypropyl)phosphoryl-phosphinic acid

PHY, 1(S)-aminoethyl-(2-carboxypropyl)phosphoryl-phosphinic acid (C6 H15 N O7 P2, 275.1 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
PHY
Formula
C6 H15 N O7 P2
Class
ligand
Structures
8
PDB entries
4

Binding sites

PHY in 8 structures; the first of them:

  • 1E4E · D-alanyl-D-lacate ligase · PHY A355 · binds GLU16, VAL19, HIS99, GLU104, GLY176, SER177, SER178, PHE241 and 11 more
  • 1EHI · D-ALANINE:D-lactate ligase (LMDDL2) of vancomycin-resistant leuconostoc mesenteroides · PHY A782 · binds GLU16, VAL19, HIS102, SER186, TYR255, LYS260, PHE261, ARG301 and 9 more
  • 1IOW · Complex of Y216F D-ALA:D-ala ligase with ADP and a phosphoryl phosphinate · PHY A320 · binds GLU15, VAL18, HIS63, GLY149, SER150, TYR210, LYS215, PHE216 and 10 more
  • 2DLN · Vancomycin resistance: structure of D-ALANINE:D-alanine ligase at 2.3 ångströms resolution · PHY A320 · binds GLU15, VAL18, HIS63, GLY149, SER150, SER151, TYR210, LYS215 and 11 more
  • 1E4E · D-alanyl-D-lacate ligase · PHY A355 · binds GLU16, VAL19, HIS99, GLU104, GLY176, SER177, SER178, PHE241 and 11 more
  • 1EHI · D-ALANINE:D-lactate ligase (LMDDL2) of vancomycin-resistant leuconostoc mesenteroides · PHY A782 · binds GLU16, VAL19, HIS102, SER186, TYR255, LYS260, PHE261, ARG301 and 9 more
  • 1IOW · Complex of Y216F D-ALA:D-ala ligase with ADP and a phosphoryl phosphinate · PHY A320 · binds GLU15, VAL18, HIS63, GLY149, SER150, TYR210, LYS215, PHE216 and 10 more
  • 2DLN · Vancomycin resistance: structure of D-ALANINE:D-alanine ligase at 2.3 ångströms resolution · PHY A320 · binds GLU15, VAL18, HIS63, GLY149, SER150, SER151, TYR210, LYS215 and 11 more

Residues it binds most

SER 10, GLU 10, GLY 10, ARG 10, HIS 10, VAL 10, ASN 10, ASP 10, PRO 10, TYR 8 (residue and the binding sites it lines).

Found with

  • ADP · Adenosine-5'-diphosphate
  • MG · Magnesium ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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