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Ligand · PFZ

PFZ · 1-(N-imidazolyl)-2-hydroxy-2-(2,3-dichlorophenyl)octane

PFZ, 1-(N-imidazolyl)-2-hydroxy-2-(2,3-dichlorophenyl)octane (C17 H22 Cl2 N2 O, 341.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
PFZ
Formula
C17 H22 Cl2 N2 O
Class
ligand
Structures
4
PDB entries
2

Binding sites

PFZ in 4 structures; the first of them:

  • 1PHA · Inhibitor-induced conformational change in cytochrome P450-cam · PFZ A422 · binds PHE87, ALA92, TYR96, PHE98, THR101, MET184, THR185, LEU244 and 10 more
  • 1PHB · Inhibitor-induced conformational change in cytochrome P450-cam · PFZ A422 · binds PRO86, PHE87, TYR96, PHE98, THR101, THR185, LEU244, VAL247 and 9 more
  • 1PHA · Inhibitor-induced conformational change in cytochrome P450-cam · PFZ A422 · binds PHE87, ALA92, TYR96, PHE98, THR101, MET184, THR185, LEU244 and 10 more
  • 1PHB · Inhibitor-induced conformational change in cytochrome P450-cam · PFZ A422 · binds PRO86, PHE87, TYR96, PHE98, THR101, THR185, LEU244, VAL247 and 9 more

Residues it binds most

THR 4, VAL 4, PHE 4, ALA 4, ASP 4, CYS 4, GLN 4, GLY 4, ILE 4, LEU 4 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe

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