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Ligand · PFG

PFG · 10-parpargyl-5,8-dideazafolate-4-glutamic acid

PFG, 10-parpargyl-5,8-dideazafolate-4-glutamic acid (C39 H44 N8 O15, 864.8 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
PFG
Formula
C39 H44 N8 O15
Class
ligand
Structures
2
PDB entries
1

Binding sites

PFG in 2 structures; the first of them:

  • 2BBQ · Structural basis for recognition of polyglutamyl folates by thymidylate synthase · PFG A531 · binds HIS51, ARG53, SER54, GLU58, THR78, ILE79, TRP80, TRP83 and 10 more
  • 2BBQ · Structural basis for recognition of polyglutamyl folates by thymidylate synthase · PFG A531 · binds HIS51, ARG53, SER54, GLU58, THR78, ILE79, TRP80, TRP83 and 10 more

Residues it binds most

LEU 4, TRP 4, ILE 4, ALA 4, ASN 4, ASP 4, GLU 4, GLY 4, HIS 4, PHE 4 (residue and the binding sites it lines).

Found with

  • UMP · 2'-deoxyuridine 5'-monophosphate

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