P8L · [(1~{S},2~{R})-2-cyclohexylcyclopropyl]methyl ~{N}-[(2~{S})-1-[[(1~{R},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$L^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate

Binding sites

P8L in 2 structures; the first of them:

• 8CZT · Structure of MERS 3CL protease in complex with the cyclopropane based inhibitor 15D · P8L A401 · binds MET25, HIS41, LEU49, PHE143, LEU144, CYS145, SER147, CYS148 and 11 more
• 8CZW · Structure of SARS-cov-2 3CL protease in complex with the cyclopropane based inhibitor 15D · P8L A402 · binds HIS41, MET49, PHE140, LEU141, ASN142, SER144, CYS145, HIS163 and 9 more

Residues it binds most

HIS 3, MET 3, CYS 3, GLN 3, LEU 3, ASP 3, GLU 3, PHE 3, SER 3, ALA 2 (residue and the binding sites it lines).

Found with

• P8U · [(1~{S},2~{R})-2-cyclohexylcyclopropyl]methyl ~{N}-[(2~{S})-1-[[(1~{S},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$L^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate
• PG4 · Tetraethylene glycol