P8C · [(1~{S},2~{R})-2-[4,4-bis(fluoranyl) cyclohexyl]cyclopropyl]methyl ~{N}-[(2~{S})-1-[[(1~{R},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$L^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate

Binding sites

P8C in 4 structures; the first of them:

• 8CZV · Structure of MERS 3CL protease in complex with the cyclopropane based inhibitor 17d · P8C A401 · binds HIS41, LEU49, TYR54, PHE143, LEU144, CYS145, GLY146, SER147 and 13 more
• 8CZX · Structure of SARS-CoV-2 3CL protease in complex with the cyclopropane based inhibitor 17d · P8C A402 · binds LEU27, HIS41, MET49, TYR54, PHE140, LEU141, ASN142, SER144 and 13 more
• 8CZV · Structure of MERS 3CL protease in complex with the cyclopropane based inhibitor 17D · P8C A401 · binds HIS41, LEU49, PHE143, LEU144, SER147, CYS148, HIS166, GLN167 and 10 more
• 8CZX · Structure of SARS-cov-2 3CL protease in complex with the cyclopropane based inhibitor 17D · P8C A402 · binds HIS41, PHE140, LEU141, ASN142, SER144, CYS145, HIS163, HIS164 and 9 more

Residues it binds most

HIS 6, LEU 5, MET 6, GLN 6, CYS 6, ASP 6, GLU 6, PHE 6, SER 6, ALA 4 (residue and the binding sites it lines).

Found with

• PJR · [(1~{S},2~{R})-2-[4,4-bis(fluoranyl) cyclohexyl]cyclopropyl]methyl ~{N}-[(2~{S})-1-[[(1~{S},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$L^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate
• PG4 · Tetraethylene glycol