Ligand · P16
P16 · 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
P16, 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (C21 H16 Cl2 N4 O2, 427.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (4 PDB entries). Every binding site with…
- Component
- P16
- Formula
- C21 H16 Cl2 N4 O2
- Class
- ligand
- Structures
- 4
- PDB entries
- 4
Binding sites
P16 in 4 structures; the first of them:
- 1OPK · Structural basis for the auto-inhibition of c-Abl tyrosine kinase · P16 A2 · binds LEU267, GLY268, TYR272, VAL275, ALA288, VAL289, LYS290, GLU305 and 14 more
- 1OPL · Structural basis for the auto-inhibition of c-Abl tyrosine kinase · P16 A539 · binds LEU267, GLY268, TYR272, VAL275, ALA288, VAL289, LYS290, GLU305 and 13 more
- 2FO0 · Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase · P16 A702 · binds LEU267, GLY268, TYR272, VAL275, GLU277, ALA288, VAL289, LYS290 and 15 more
- 2G2H · A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain · P16 A532 · binds LEU267, GLY268, TYR272, VAL275, ALA288, VAL289, LYS290, MET309 and 13 more
Residues it binds most
VAL 6, ALA 6, GLU 6, GLY 6, LEU 6, MET 6, PHE 6, THR 6, TYR 6, ASP 6 (residue and the binding sites it lines).
Found with
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