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Ligand · OV5

OV5 · 6-{[(2M)-2-(2-chloro-6-fluorophenyl)-5-oxo-5H-pyrrolo[3,4-b]pyridin-4-yl]amino}-N-ethylpyridine-3-carboxamide

OV5, 6-{[(2M)-2-(2-chloro-6-fluorophenyl)-5-oxo-5H-pyrrolo[3,4-b]pyridin-4-yl]amino}-N-ethylpyridine-3-carboxamide (C21 H15 Cl F N5 O2, 423.8 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding…

Component
OV5
Formula
C21 H15 Cl F N5 O2
Class
ligand
Structures
3
PDB entries
2

Binding sites

OV5 in 3 structures; the first of them:

  • 7UYT · Crystal structure of TYK2 kinase domain in complex with compound 25 · OV5 A1201 · binds ARG901, LEU903, GLY904, GLU905, GLY906, VAL911, ALA928, ILE960 and 13 more
  • 7UYT · Crystal structure of TYK2 kinase domain in complex with compound 25 · OV5 A1201 · binds ARG901, LEU903, GLY904, GLU905, VAL911, ALA928, MET978, GLU979 and 10 more
  • 7UYV · Crystal structure of JAK3 kinase domain in complex with compound 25 · OV5 A1201 · binds LEU828, GLY829, VAL836, ALA853, VAL884, GLU903, TYR904, LEU905 and 5 more

Residues it binds most

LEU 6, GLY 6, ALA 6, VAL 6, GLU 6, ASP 5, ASN 6, TYR 6, ARG 2, MET 3 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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